Structure and molecular mechanism of bacterial transcription activation

Dmytro Kompaniiets; Dong Wang; Yang Yang; Yangbo Hu; Bin Liu

doi:10.1016/j.tim.2023.10.001

Structure and molecular mechanism of bacterial transcription activation

Dmytro Kompaniiets, Dong Wang, Yang Yang, Yangbo Hu, Bin Liu

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Transcription activation is an important checkpoint of regulation of gene expression which occurs in response to different intracellular and extracellular signals. The key elements in this signal transduction process are transcription activators, which determine when and how gene expression is activated. Recent structural studies on a considerable number of new transcription activation complexes (TACs) revealed the remarkable mechanistic diversity of transcription activation mediated by different factors, necessitating a review and re-evaluation of the transcription activation mechanisms. In this review, we present a comprehensive summary of transcription activation mechanisms and propose a new, elaborate, and systematic classification of transcription activation mechanisms, primarily based on the structural features of diverse TAC components.

Original language	English (US)
Journal	Trends in Microbiology
DOIs	https://doi.org/10.1016/j.tim.2023.10.001
State	Published - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Keywords

DNA promoter
gene regulation
RNA polymerase
sigma factor
transcription activation
transcription factor

PubMed: MeSH publication types

Journal Article
Review

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10.1016/j.tim.2023.10.001

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@article{d6bba8f28c4d4652b3777a63db26d4bb,

title = "Structure and molecular mechanism of bacterial transcription activation",

abstract = "Transcription activation is an important checkpoint of regulation of gene expression which occurs in response to different intracellular and extracellular signals. The key elements in this signal transduction process are transcription activators, which determine when and how gene expression is activated. Recent structural studies on a considerable number of new transcription activation complexes (TACs) revealed the remarkable mechanistic diversity of transcription activation mediated by different factors, necessitating a review and re-evaluation of the transcription activation mechanisms. In this review, we present a comprehensive summary of transcription activation mechanisms and propose a new, elaborate, and systematic classification of transcription activation mechanisms, primarily based on the structural features of diverse TAC components.",

keywords = "DNA promoter, gene regulation, RNA polymerase, sigma factor, transcription activation, transcription factor",

author = "Dmytro Kompaniiets and Dong Wang and Yang Yang and Yangbo Hu and Bin Liu",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = oct,

doi = "10.1016/j.tim.2023.10.001",

language = "English (US)",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Structure and molecular mechanism of bacterial transcription activation

AU - Kompaniiets, Dmytro

AU - Wang, Dong

AU - Yang, Yang

AU - Hu, Yangbo

AU - Liu, Bin

PY - 2023/10

Y1 - 2023/10

N2 - Transcription activation is an important checkpoint of regulation of gene expression which occurs in response to different intracellular and extracellular signals. The key elements in this signal transduction process are transcription activators, which determine when and how gene expression is activated. Recent structural studies on a considerable number of new transcription activation complexes (TACs) revealed the remarkable mechanistic diversity of transcription activation mediated by different factors, necessitating a review and re-evaluation of the transcription activation mechanisms. In this review, we present a comprehensive summary of transcription activation mechanisms and propose a new, elaborate, and systematic classification of transcription activation mechanisms, primarily based on the structural features of diverse TAC components.

AB - Transcription activation is an important checkpoint of regulation of gene expression which occurs in response to different intracellular and extracellular signals. The key elements in this signal transduction process are transcription activators, which determine when and how gene expression is activated. Recent structural studies on a considerable number of new transcription activation complexes (TACs) revealed the remarkable mechanistic diversity of transcription activation mediated by different factors, necessitating a review and re-evaluation of the transcription activation mechanisms. In this review, we present a comprehensive summary of transcription activation mechanisms and propose a new, elaborate, and systematic classification of transcription activation mechanisms, primarily based on the structural features of diverse TAC components.

KW - DNA promoter

KW - gene regulation

KW - RNA polymerase

KW - sigma factor

KW - transcription activation

KW - transcription factor

UR - https://doi.org/10.1016/j.tim.2023.10.001

U2 - 10.1016/j.tim.2023.10.001

DO - 10.1016/j.tim.2023.10.001

M3 - Review article

C2 - 37903670

SN - 0966-842X

JO - Trends in Microbiology

JF - Trends in Microbiology

ER -

Structure and molecular mechanism of bacterial transcription activation

Abstract

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Keywords

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