Structure and mode of peptide binding of pheromone receptor PrgZ

Ronnie P.A. Berntsson, Gea K. Schuurman-Wolters, Gary Dunny, Dirk Jan Slotboom, Bert Poolman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: A sex pheromone system controls bacterial conjugation. Results: The initial receptor PrgZ has been crystallized in complex with the sex pheromone cCF10. Conclusion: An extensive network of hydrogen bonds explains the high peptide specificity of PrgZ. Significance: The sex pheromone and inhibitor peptide compete for binding to PrgZ, providing new insight into the regulation of conjugation.

Original languageEnglish (US)
Pages (from-to)37165-37170
Number of pages6
JournalJournal of Biological Chemistry
Issue number44
StatePublished - Oct 26 2012


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