Structure and function of dioxygenases. One approach to lignin degradation

John M. Wood, Ronald L. Crawford, James B. Howard, William H. Orme-johnson, John D Lipscomb, John W. Bromley, R. Scott Stephens, Eckard Münck, Reinhart Zimmerman, Larry Que

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The evolution of biosynthetic pathways leading to the formation of those structural natural products found in higher plants occurred in an oxygen-rich environment. Mixed function oxygenases evolved and functioned in catalyzing the insertion of molecular oxygen into basic structural polymers such as lignin, as well as natural products such as flavanoids and alkaloids. In addition to the critical role played by molecular oxygen in biosynthesis, oxidative degradative pathways evolved for the return of these natural products to the carbon cycle in the form of carbon dioxide. Oxidative degradation of natural products occurs by oxygen insertion reactions which are catalyzed by the mixed function oxygenases and by the dioxygenases. Reaction mechanisms for the mixed function oxygenases are now quite well understood, and a number of chemical model systems have been designed which catalyze such oxidation reactions. However, at the present time we do not have enough pertinent information on the mechanism of action of dioxygenases. This report provides some information to allow for the design of chemical model systems which mimic dioxygenase activity.

Original languageEnglish (US)
Pages (from-to)698-704
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume25
Issue number4
DOIs
StatePublished - Jul 1 1977

Fingerprint

Dioxygenases
Lignin
Biological Products
mixed function oxidase
lignin
Mixed Function Oxygenases
Oxygen
Chemical Models
oxygen
Degradation
degradation
Molecular oxygen
flavanoids
Carbon Cycle
reaction mechanisms
Biosynthesis
Biosynthetic Pathways
Alkaloids
Carbon Dioxide
biochemical pathways

Cite this

Structure and function of dioxygenases. One approach to lignin degradation. / Wood, John M.; Crawford, Ronald L.; Howard, James B.; Orme-johnson, William H.; Lipscomb, John D; Bromley, John W.; Stephens, R. Scott; Münck, Eckard; Zimmerman, Reinhart; Que, Larry.

In: Journal of Agricultural and Food Chemistry, Vol. 25, No. 4, 01.07.1977, p. 698-704.

Research output: Contribution to journalArticle

Wood, JM, Crawford, RL, Howard, JB, Orme-johnson, WH, Lipscomb, JD, Bromley, JW, Stephens, RS, Münck, E, Zimmerman, R & Que, L 1977, 'Structure and function of dioxygenases. One approach to lignin degradation', Journal of Agricultural and Food Chemistry, vol. 25, no. 4, pp. 698-704. https://doi.org/10.1021/jf60212a028
Wood, John M. ; Crawford, Ronald L. ; Howard, James B. ; Orme-johnson, William H. ; Lipscomb, John D ; Bromley, John W. ; Stephens, R. Scott ; Münck, Eckard ; Zimmerman, Reinhart ; Que, Larry. / Structure and function of dioxygenases. One approach to lignin degradation. In: Journal of Agricultural and Food Chemistry. 1977 ; Vol. 25, No. 4. pp. 698-704.
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AU - Lipscomb, John D

AU - Bromley, John W.

AU - Stephens, R. Scott

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