TY - JOUR
T1 - Structure and function of apolipoprotein A-I and high-density lipoprotein
AU - Segrest, Jere P.
AU - Li, Ling
AU - Anantharamaiah, G. M.
AU - Harvey, Stephen C.
AU - Liadaki, Kalliopi N.
AU - Zannis, Vassilis
PY - 2000
Y1 - 2000
N2 - Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in such biological processes as ABC1-regulated HDL assembly, LCAT activation, receptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL research. (C) 2000 Lippincott Williams and Wilkins.
AB - Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in such biological processes as ABC1-regulated HDL assembly, LCAT activation, receptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL research. (C) 2000 Lippincott Williams and Wilkins.
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U2 - 10.1097/00041433-200004000-00002
DO - 10.1097/00041433-200004000-00002
M3 - Review article
C2 - 10787171
AN - SCOPUS:0034089149
SN - 0957-9672
VL - 11
SP - 105
EP - 115
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
IS - 2
ER -