Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters

Mathias Misiek, Jessica Williams, Kathrin Schmich, Wolfgang Hüttel, Irmgard Merfort, Christine E. Salomon, Courtney C. Aldrich, Dirk Hoffmeister

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

We report on the structure elucidation of arnamial, a new Δ2,4-protoilludane everninate ester from the fungus Armillaria mellea, and on the apoptotic activity of arnamial as well as the cytotoxic activity of structurally related compounds on selected human cancer cells. Arnamial showed cytotoxicity against Jurkat T cells, MCF-7 breast adenocarcinoma, CCRFCEM lymphoblastic leukemia, and HCT-116 colorectal carcinoma cells at IC50 ) 3.9, 15.4, 8.9, and 10.7 μM, respectively, and the related aryl ester melledonal C showed cytotoxic activity against CCRF-CEM cells (IC50 ) 14.75 μM). [1,2-13C2]Acetate feeding supports a polyketide origin of the orsellinic acid moiety of arnamial.

Original languageEnglish (US)
Pages (from-to)1888-1891
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
StatePublished - Oct 23 2009

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