Structure and antioxidant activity of six mushroom-derived heterogalactans

Yunhe Qu, Jingmin Yan, Xin Zhang, Chengcheng Song, Mengshan Zhang, Kevin H. Mayo, Lin Sun, Hairong Cheng, Yifa Zhou

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Heterogalactans with weight-average molecular weights ~20 kDa were purified from several species of mushroom: Hypsizygus marmoreus, Pleurotus ostreatus, Pholiota nameko, Agrocybe cylindracea, Hygrophorus lucorum and Hericium erinaceus, and structurally characterized and assessed for antioxidant activity in vitro. Methylation analysis, combined with NMR spectral analysis, indicates that these glycans have a common backbone composed of (1 → 6)-linked-α-D-galactopyranosyl residues that are substituted at O-2. The (1 → 6)-α-D-galactans, branched primarily with β-D-mannopyranosyl (Manp) or α-L-fucopyranosyl (Fucp) residues, have been assigned to mannogalactans or fucogalactans, respectively, as well as to β-D-Manp and α-L-Fucp residues attached in tandem to the main chain as fucomannogalactans. In addition, 3-O-methylated-α-D-galactopyranosyl (3-O-Me-Galp) residues within the mannogalactan chains, exhibit strong reducing power and radical scavenging activity suggesting that this sugar moiety functions as an antioxidant. Our results provide important structural information on mushroom heterogalactans and prompt further investigations into their structure-activity relationships.

Original languageEnglish (US)
Pages (from-to)1439-1449
Number of pages11
JournalInternational Journal of Biological Macromolecules
Volume209
Issue numberPt A
DOIs
StatePublished - Jun 1 2022

Bibliographical note

Funding Information:
This work was supported by the Scientific and Technologic Foundation of Jilin Province ( 20200708059YY ), the National Natural Science Foundation of China ( 22007011 ), and the Fundamental Research Funds for the Central Universities ( 2412020FZ018 , 2412021ZD010 ).

Publisher Copyright:
© 2022

Keywords

  • Antioxidant activity
  • Fucogalactans
  • Fucomannogalactans
  • Mannogalactans
  • Structural characterization

PubMed: MeSH publication types

  • Journal Article

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