Structure-activity relationships (SAR) of melanocortin and agouti-related (AGRP) peptides

Anamika Singh, Erica M. Haslach, Carrie Haskell-Luevano

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Structure-activity relationship (SAR) studies are a key feature of peptide and peptidomimetic research to improve the biological properties of native peptides and convert them into more drug-like compounds. Peptide SAR studies involve the systematic modification of a lead peptide to provide insight into the molecular determinants of the ligand-receptor interactions that result in either receptor stimulation or inhibition. This chapter will discuss structure-activity relationships of the endogenous and synthetic agonists and the antagonists of the melanocortin system.

Original languageEnglish (US)
Title of host publicationMelanocortins
Subtitle of host publicationMultiple Actions and Therapeutic Potential
Pages1-18
Number of pages18
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume681
ISSN (Print)0065-2598

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    Singh, A., Haslach, E. M., & Haskell-Luevano, C. (2010). Structure-activity relationships (SAR) of melanocortin and agouti-related (AGRP) peptides. In Melanocortins: Multiple Actions and Therapeutic Potential (pp. 1-18). (Advances in Experimental Medicine and Biology; Vol. 681). https://doi.org/10.1007/978-1-4419-6354-3_1