Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures

Keyphrases

• Acid Activation 100%
• Acid Concentration 16%
• Acyl-CoA Dehydrogenase 33%
• Alpha Activation 16%
• Carbon Chain Length 16%
• Carboxylate 16%
• Carboxylic Acids 16%
• Cell Injury 33%
• Cells in Culture 16%
• Chain Length 16%
• DDIT3 16%
• Dose Effect 16%
• Gene Expression 66%
• Gene Targeting 16%
• Gene Transcription 16%
• HepG2 16%
• Human Health Problems 16%
• Human Liver Cells 50%
• Human Relevance 100%
• Length-dependent 16%
• Liver Cell Culture 100%
• Liver Toxicity 16%
• Perfluoroalkyl Acids 100%
• Perfluorobutanoic Acid 33%
• Perfluorohexanoic Acid (PFHxA) 83%
• Peroxisome Proliferation 100%
• Peroxisome Proliferator-activated Receptor 100%
• Potential Toxicity 33%
• Primary Rat Hepatocytes 50%
• Rat Hepatocytes 16%
• Rat Liver Cells 16%
• Rodents 33%
• Structure-activity Relationship 100%
• Structure-activity Relationship Studies 16%
• Sulfonate 16%
• Sulfonic Acid 16%
• Transcriptional Activation 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Acyl Coenzyme A Oxidase 33%
• Carboxylate 33%
• Cell Culture 100%
• Hepatotoxicity 16%
• Injury 33%
• Perfluorooctanesulfonic Acid 16%
• Perfluorooctanoic Acid 66%
• Peroxisome Proliferator Activated Receptor Alpha 100%
• Structure Activity Relationship 100%
• Sulfonate 16%
• Sulfonic Acid 16%