Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

Douglas H. Ohiendorf, Steven I. Foundling, John J. Wendoloski, Juraj Sedlacek, Peter Strop, F. Raymond Salemme

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 Å resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase‐inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)382-391
Number of pages10
JournalProteins: Structure, Function, and Bioinformatics
Volume14
Issue number3
DOIs
StatePublished - Nov 1992

Keywords

  • avian myeloblastosis associated virus
  • enzyme‐substrate interactions
  • macromolecular modelling
  • protein crystallography
  • retroviral aspartate proteinases

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