TY - JOUR
T1 - Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
AU - Ohiendorf, Douglas H.
AU - Foundling, Steven I.
AU - Wendoloski, John J.
AU - Sedlacek, Juraj
AU - Strop, Peter
AU - Salemme, F. Raymond
PY - 1992/11
Y1 - 1992/11
N2 - The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 Å resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase‐inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases. © 1992 Wiley‐Liss, Inc.
AB - The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 Å resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase‐inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases. © 1992 Wiley‐Liss, Inc.
KW - avian myeloblastosis associated virus
KW - enzyme‐substrate interactions
KW - macromolecular modelling
KW - protein crystallography
KW - retroviral aspartate proteinases
UR - http://www.scopus.com/inward/record.url?scp=0026761796&partnerID=8YFLogxK
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U2 - 10.1002/prot.340140307
DO - 10.1002/prot.340140307
M3 - Article
C2 - 1332025
AN - SCOPUS:0026761796
SN - 0887-3585
VL - 14
SP - 382
EP - 391
JO - Proteins: Structure, Function and Bioinformatics
JF - Proteins: Structure, Function and Bioinformatics
IS - 3
ER -
