Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor

Keyphrases

• Small Molecule Inhibitors 100%
• Structural Insights 100%
• Induced Fit 100%
• Fascin 100%
• Small Molecules 25%
• Tumor Metastasis 25%
• Tumor Cell Migration 25%
• Filopodia 16%
• Tumor Cell Invasion 16%
• Molecular Mechanism 8%
• Protein Function 8%
• Mechanism of Action 8%
• Cell Surface 8%
• All Cancer 8%
• Cancer Mortality 8%
• Binding Site 8%
• Actin-binding Proteins 8%
• Actin Binding 8%
• Migration Invasion 8%
• Crystal Structural Analysis 8%
• X-ray Crystal 8%
• Interacting Residues 8%
• Surface Extension 8%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Fascin 100%
• Cell Migration 25%
• Actin 16%
• Filopodia 16%
• X Ray 8%
• Protein Function 8%
• Conformation 8%
• Crystal Structure 8%
• Cancer Mortality 8%
• Binding Site 8%
• Cell Invasion 8%