Structural Insights into the Distinct Solid-State Properties and Interconversion of Celecoxib N-Methyl-2-pyrrolidone Solvates

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Abstract

In an effort to develop a tablet product of celecoxib by overcoming its poor physicochemical properties using a pharmaceutically acceptable solvate, we isolated two stoichiometric N-Methyl-2-Pyrrolidone (NMP) solvates of celecoxib (CEL), mono-NMP and di-NMP solvates. Here, we report the preparation, characterization, and structural origin of different properties of the two CEL solvates, including a rare and complex heating induced phase transformation from di-NMP to mono-NMP solvate.

Original languageEnglish (US)
Pages (from-to)277-286
Number of pages10
JournalCrystal Growth and Design
Volume21
Issue number1
DOIs
StatePublished - Nov 24 2020

Bibliographical note

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© 2020 American Chemical Society.

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