Structural insights into central hypertension regulation by human aminopeptidase A

Yang Yang, Chang Liu, Yi Lun Lin, Fang Li

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background:HumanaminopeptidaseA(APA) regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides. Results: We determined the crystal structures of APA complexed with different ligands and calcium. Conclusion: The S1 pocket of APA contains a calcium-binding site and accommodates only acidic residues. Significance: This study elucidates the calcium-modulated substrate specificity of APA and will aid in the development of antihypertensive APA inhibitors.

Original languageEnglish (US)
Pages (from-to)25638-25645
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

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