Structural features of the uniporter/symporter/antiporter superfamily

Visala Chepuri Goswitz, Robert J. Brooker

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three‐dimensional arrangement of the transmembrane domains.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalProtein Science
Issue number3
StatePublished - Mar 1995


  • antiporter
  • lactose permease
  • symporter
  • uniporter


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