Structural biology of RNA silencing and its functional implications

D. J. Patel; J. B. Ma; Y. R. Yuan; K. Ye; Y. Pei; V. Kuryavyi; L. Malinina; G. Meister; T. Tuschl

doi:10.1101/sqb.2006.71.053

Structural biology of RNA silencing and its functional implications

D. J. Patel, J. B. Ma, Y. R. Yuan, K. Ye, Y. Pei, V. Kuryavyi, L. Malinina, G. Meister, T. Tuschl

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32 Scopus citations

Abstract

We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.

Original language	English (US)
Pages (from-to)	81-93
Number of pages	13
Journal	Cold Spring Harbor symposia on quantitative biology
Volume	71
DOIs	https://doi.org/10.1101/sqb.2006.71.053
State	Published - 2006
Externally published	Yes

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10.1101/sqb.2006.71.053

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author = "Patel, {D. J.} and Ma, {J. B.} and Yuan, {Y. R.} and K. Ye and Y. Pei and V. Kuryavyi and L. Malinina and G. Meister and T. Tuschl",

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AU - Ma, J. B.

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AU - Malinina, L.

AU - Meister, G.

AU - Tuschl, T.

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AB - We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.

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Structural biology of RNA silencing and its functional implications

Abstract

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