We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.
|Original language||English (US)|
|Number of pages||13|
|Journal||Cold Spring Harbor symposia on quantitative biology|
|State||Published - 2006|