Structural biology of RNA silencing and its functional implications

D. J. Patel, J. B. Ma, Y. R. Yuan, K. Ye, Y. Pei, V. Kuryavyi, L. Malinina, G. Meister, T. Tuschl

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalCold Spring Harbor symposia on quantitative biology
StatePublished - 2006

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