Structural biology of metal-binding sequences

Stanley J. Opella, Tara M. DeSilva, Gianluigi Veglia

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and sequestering systems across different species, and the need to continue the research to confirm hypotheses for the molecular mechanisms of transfers of metal ions between proteins.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalCurrent opinion in chemical biology
Issue number2
StatePublished - Apr 1 2002

Bibliographical note

Funding Information:
We thank R Steele, A Prantner, G Porcelli, Y Coppel and D Brabazon for their participation in the research described in this article. This research was supported by grants R823576 from the Environmental Protection Agency, DE-F607-97ER62314 from the Department of Energy, and RO1GM29754 and P41RR09793 from the National Institutes of Health.


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