Structural basis of motility in the microtubular axostyle: Implications for cytoplasmic microtubule structure and function

D. T. Woodrum, R. W. Linck

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The gross morphology of the protozoan microtubule axostyle of Saccinobaculus ambloaxostylus can now be described in macromolecular detail. The left-handed coil of the axostyle is seen to be dependent upon the asymmetry inherent in the constituent microtubules as expressed by the specific array of linkages between microtubules and by a possible tendency for microtubules to coil into left-handed helices. The laminated sheets of microtubules are not aligned parallel to the long axis of the organelle, but become increasingly tilted off-axis as one descends through the sheets of microtubules from the convex to the concave surface of the axostyle. Fine-structural analysis of the axostyle indicates similarities of the linkages to dynein. The potential loci of the force-generating protein(s) are discussed as well as implications of the axostyle’s structure on general microtubule function.

Original languageEnglish (US)
Pages (from-to)404-414
Number of pages11
JournalJournal of Cell Biology
Volume87
Issue number2
DOIs
StatePublished - Nov 1 1980

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