Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex

Eric A. Hendrickson, Joy L. Huffman, John A. Tainer

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.

Original languageEnglish (US)
Title of host publicationDNA Damage Recognition
PublisherCRC Press
Number of pages56
ISBN (Electronic)9780849352683
ISBN (Print)9780824759612
StatePublished - Jan 1 2005

Bibliographical note

Publisher Copyright:
© 2005 by Taylor and Francis Group, LLC.


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