Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex

Eric A. Hendrickson, Joy L. Huffman, John A. Tainer

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

DNA-dependent protein kinase (DNA-PK) is a trimeric complex comprised of the DNA-PK catalytic subunit (DNA-PKcs) and the autoantigens, Ku86 and Ku70. DNA-dependent protein kinase has attracted enormous interest because it is critically important for four distinct, but probably mechanistically overlapping, processes in vertebrate cells: (i) the generation of a functional immune system through lymphoid variable(diversity)joining [V(D)J] recombination, (ii) immunoglobulin isotype switch recombination, (iii) the repair of spontaneous and exogenously generated DNA double-strand breaks (DSBs) via nonhomologous end joining (NHEJ), and (iv) telomere length maintenance and function.

Original languageEnglish (US)
Title of host publicationDNA Damage Recognition
PublisherCRC Press
Pages629-684
Number of pages56
ISBN (Electronic)9780849352683
ISBN (Print)9780824759612
DOIs
StatePublished - Jan 1 2005

Bibliographical note

Publisher Copyright:
© 2005 by Taylor and Francis Group, LLC.

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