Structural analysis of the evolutionary origins of influenza virus hemagglutinin and other viral lectins programming

Lang Chen, Fang Li

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Influenza virus and other viruses use host cell surface sugars as receptors. Here we show that the sugar-binding domains in influenza virus hemagglutinin and other viral lectins share the same structural fold as human galectins (host lectins). Unlike the easily accessible sugar-binding sites in human galectins, the sugar-binding sites in viral lectins are hidden in cavities. We propose that these viral lectins originated from host lectins but have evolved to use hidden sugar-binding sites to evade host immune attacks.

Original languageEnglish (US)
Pages (from-to)4118-4120
Number of pages3
JournalJournal of virology
Volume87
Issue number7
DOIs
StatePublished - Apr 2013

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