Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Zhang et al. determine a series of crystal structures of TLR7 complexed with agonistic ligands. The findings contain detailed ssRNA sequence specificity, recognition mechanism(s) of synthetic ligands, the molecular basis of TLR7 and TLR8 ligand selectivity, and identification of possible endogenous ligands with a high activity.

Original languageEnglish (US)
Pages (from-to)3371-3381.e5
JournalCell reports
Volume25
Issue number12
DOIs
StatePublished - Dec 18 2018

Keywords

  • Toll-like receptor
  • guanosine 2′,3′-cyclic phosphate
  • innate immunity
  • low-molecular-weight agonists
  • single-stranded RNA

Fingerprint Dive into the research topics of 'Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands'. Together they form a unique fingerprint.

Cite this