Zhang et al. determine a series of crystal structures of TLR7 complexed with agonistic ligands. The findings contain detailed ssRNA sequence specificity, recognition mechanism(s) of synthetic ligands, the molecular basis of TLR7 and TLR8 ligand selectivity, and identification of possible endogenous ligands with a high activity.
- Toll-like receptor
- guanosine 2′,3′-cyclic phosphate
- innate immunity
- low-molecular-weight agonists
- single-stranded RNA