Stromal-derived factor-lα (CXCL 12) leveis increase in periodontal disease

Aaron M. Havens, Evonne Chiu, Mario Taba, Jincheng Wang, Yusuke Shiozawa, Younghun Jung, L. Susan Taichman, Nisha J. D'Silva, R. Gopalakrishnan, Cunyu Wang, William V. Giannobile, Russell S. Taichman

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal cell-derived factor-1 (SDF-Iα or CXC chemokine ligand 12) are involved in the trafficking of leukocytes into and out of extravascular tissues. The purpose of this study was to determine whether SDF-1α secreted by host cells plays a role in recruiting inflammatory cells into the periodontia during local inflammation. Methods: SDF-1α levels were determined by enzyme-linked immunosorbent assay in gingival crevicular fluid (GCF) of 24 individuals with periodontitis versus healthy individuals in tissue biopsies and in a preclinical rat model of Porphyromonas gingivalis lipopoly-saccharide-induced experimental bone loss. Neutrophil Chemotaxis assays were also used to evaluate whether SDF-1α plays a role in the recruitment of host cells at periodontal lesions. Results: Subjects with periodontal disease had higher levels of SDF-1α in their GCF compared to healthy subjects. Subjects with periodontal disease who underwent mechanical therapy demonstrated decreased levels of SDF-1α. Immunohistologic staining showed that SDF-1α and CXCR4 levels were elevated in samples obtained from periodontally compromised individuals. Similar results were observed in the rodent model. Neutrophil migration was enhanced in the presence of SDF-1α, mimicking immune cell migration in periodontal lesions. Conclusions: SDF-1α may be involved in the immune defense pathway activated during periodontal disease. Upon the development of diseased tissues, SDF-1α levels increase and may recruit host defensive cells into sites of inflammation. These studies suggest that SDF-1α may be a useful biomarker for the identification of periodontal disease progression.

Original languageEnglish (US)
Pages (from-to)845-853
Number of pages9
JournalJournal of periodontology
Issue number5
StatePublished - May 2008


  • CXCL12
  • CXCR4
  • Chemokine
  • Inflammation
  • Periodontitis
  • SDF-1α


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