Striatal synapses, circuits, and Parkinson's disease

Shenyu Zhai; Asami Tanimura; Steven M. Graves; Weixing Shen; D. James Surmeier

doi:10.1016/j.conb.2017.08.004

Striatal synapses, circuits, and Parkinson's disease

Shenyu Zhai, Asami Tanimura, Steven M. Graves, Weixing Shen, D. James Surmeier

Pharmacology

Research output: Contribution to journal › Review article › peer-review

121 Scopus citations

Abstract

The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.

Original language	English (US)
Pages (from-to)	9-16
Number of pages	8
Journal	Current opinion in neurobiology
Volume	48
DOIs	https://doi.org/10.1016/j.conb.2017.08.004
State	Published - Feb 2018

Bibliographical note

Funding Information:
This work was supported by grants from JPB, CHDI, IDP and NS34696 to D.J.S.; Bumpus Foundation postdoctoral fellowship to S.Z.; and Parkinson's Disease Foundation postdoctoral fellowship to A.T. We thank members of the Surmeier lab for helpful comments.

Publisher Copyright:
© 2017

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10.1016/j.conb.2017.08.004

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022405

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title = "Striatal synapses, circuits, and Parkinson's disease",

abstract = "The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.",

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AU - Tanimura, Asami

AU - Graves, Steven M.

AU - Shen, Weixing

AU - Surmeier, D. James

N1 - Funding Information: This work was supported by grants from JPB, CHDI, IDP and NS34696 to D.J.S.; Bumpus Foundation postdoctoral fellowship to S.Z.; and Parkinson's Disease Foundation postdoctoral fellowship to A.T. We thank members of the Surmeier lab for helpful comments. Publisher Copyright: © 2017

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AB - The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.

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Striatal synapses, circuits, and Parkinson's disease

Abstract

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