The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.
Bibliographical noteFunding Information:
This work was supported by grants from JPB, CHDI, IDP and NS34696 to D.J.S.; Bumpus Foundation postdoctoral fellowship to S.Z.; and Parkinson's Disease Foundation postdoctoral fellowship to A.T. We thank members of the Surmeier lab for helpful comments.