Striatal synapses, circuits, and Parkinson's disease

Shenyu Zhai, Asami Tanimura, Steven M. Graves, Weixing Shen, D. James Surmeier

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in the hypokinetic features of the disease. New tools to study brain circuitry have led to significant advances in our understanding of striatal circuits and how they adapt in PD models. This short review summarizes some of these recent studies and the gaps that remain to be filled.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalCurrent opinion in neurobiology
Volume48
DOIs
StatePublished - Feb 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from JPB, CHDI, IDP and NS34696 to D.J.S.; Bumpus Foundation postdoctoral fellowship to S.Z.; and Parkinson's Disease Foundation postdoctoral fellowship to A.T. We thank members of the Surmeier lab for helpful comments.

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