Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types

Günter P. Wagner, Eric M. Erkenbrack, Alan C. Love

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress-induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity-based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre-existing characters.

Original languageEnglish (US)
Article number1800188
JournalBioEssays
Volume41
Issue number4
DOIs
StatePublished - Apr 1 2019

Bibliographical note

Funding Information:
This work was funded by John Templeton Foundation Grant #54860 awarded to G.P.W. and A.C.L., as well as a Revson Foundation Senior Biomedical Fellowship to E.M.E. Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number U54CA209992. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Keywords

  • cell type origin
  • evolutionary innovation
  • novelty
  • plasticity
  • stress response

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

Fingerprint Dive into the research topics of 'Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types'. Together they form a unique fingerprint.

Cite this