Stress-induced eating is mediated through endogenous opiates

John E. Morley, Allen S. Levine

Research output: Contribution to journalArticlepeer-review

248 Scopus citations


The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opiate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given naloxone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.

Original languageEnglish (US)
Pages (from-to)1259-1261
Number of pages3
Issue number4462
StatePublished - 1980
Externally publishedYes


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