Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus

Johannes Thome, Brigitte Pesold, Miriam Baader, Mei Hu, Jonathan C Gewirtz, Ronald S. Duman, Fritz A. Henn

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Background: In view of the effects of stress on synaptic plasticity, the regulation of synaptophysin and synaptotagmin expression by immobilization was analyzed by in situ hybridization. Methods: Rats were exposed to immobilization stress, which induced typical behavioral alterations, such as reduced locomotor activity after stress exposure. Determination of mRNA levels of the integral synaptic vesicle proteins was performed immediately after acute or chronic immobilization. Results: The results demonstrate that stress exposure leads to reduced expression of synaptophysin but increased expression of synaptotagmin in the hippocampus. Conclusions: This rapid and differential regulation of synaptic vesicle proteins could be responsible for some of the morphological, biochemical, and behavioral changes observed after stress exposure. These changes may be relevant to such clinical disorders as psychoses, depression, and posttraumatic stress disorder that are sensitive to stress and involve changes in neural and synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)809-812
Number of pages4
JournalBiological psychiatry
Volume50
Issue number10
DOIs
StatePublished - Nov 15 2001

Keywords

  • Immobilization stress
  • Locomotor activity
  • Neural plasticity
  • Synaptic vesicle proteins

Fingerprint Dive into the research topics of 'Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus'. Together they form a unique fingerprint.

Cite this