TY - JOUR
T1 - Stress CMR in patients with obesity
T2 - insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry
AU - Ge, Yin
AU - Steel, Kevin
AU - Antiochos, Panagiotis
AU - Bingham, Scott
AU - Abdullah, Shuaib
AU - Mikolich, J. Ronald
AU - Arai, Andrew E.
AU - Bandettini, W. Patricia
AU - Shanbhag, Sujata M.
AU - Patel, Amit R.
AU - Farzaneh-Far, Afshin
AU - Heitner, John F.
AU - Shenoy, Chetan
AU - Leung, Steve W.
AU - Gonzalez, Jorge A.
AU - Shah, Dipan J.
AU - Raman, Subha V.
AU - Nawaz, Haseeb
AU - Ferrari, Victor A.
AU - Schulz-Menger, Jeanette
AU - Stuber, Matthias
AU - Simonetti, Orlando P.
AU - Kwong, Raymond Y.
N1 - Publisher Copyright:
© 2020 Published on behalf of the European Society of Cardiology.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - AIMS: Non-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magnetic resonance imaging (CMR) in a multicentre registry.METHODS AND RESULTS: The SPINS Registry enrolled consecutive intermediate-risk patients who presented with a clinical indication for stress CMR in the USA between 2008 and 2013. Baseline demographic data including BMI, CMR indices, and ratings of study quality were collected. Primary outcome was defined by a composite of cardiovascular death and non-fatal myocardial infarction. Of the 2345 patients with available BMI included in the SPINS cohort, 1177 (50%) met criteria for obesity (BMI ≥ 30) with 531 (23%) at or above Class 2 obesity (BMI ≥ 35). In all BMI categories, >95% of studies were of diagnostic quality for cine, perfusion, and late gadolinium enhancement (LGE) sequences. At a median follow-up of 5.4 years, those without ischaemia and LGE experienced a low annual rate of hard events (<1%), across all BMI strata. In patients with obesity, both ischaemia [hazard ratio (HR): 2.14; 95% confidence interval (CI): 1.30-3.50; P = 0.003] and LGE (HR: 3.09; 95% CI: 1.83-5.22; P < 0.001) maintained strong adjusted association with the primary outcome in a multivariable Cox regression model. Downstream referral rates to coronary angiography, revascularization, and cost of care spent on ischaemia testing did not significantly differ within the BMI categories.CONCLUSION: In this large multicentre registry, elevated BMI did not negatively impact the diagnostic quality and the effectiveness of risk stratification of patients referred for stress CMR.
AB - AIMS: Non-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magnetic resonance imaging (CMR) in a multicentre registry.METHODS AND RESULTS: The SPINS Registry enrolled consecutive intermediate-risk patients who presented with a clinical indication for stress CMR in the USA between 2008 and 2013. Baseline demographic data including BMI, CMR indices, and ratings of study quality were collected. Primary outcome was defined by a composite of cardiovascular death and non-fatal myocardial infarction. Of the 2345 patients with available BMI included in the SPINS cohort, 1177 (50%) met criteria for obesity (BMI ≥ 30) with 531 (23%) at or above Class 2 obesity (BMI ≥ 35). In all BMI categories, >95% of studies were of diagnostic quality for cine, perfusion, and late gadolinium enhancement (LGE) sequences. At a median follow-up of 5.4 years, those without ischaemia and LGE experienced a low annual rate of hard events (<1%), across all BMI strata. In patients with obesity, both ischaemia [hazard ratio (HR): 2.14; 95% confidence interval (CI): 1.30-3.50; P = 0.003] and LGE (HR: 3.09; 95% CI: 1.83-5.22; P < 0.001) maintained strong adjusted association with the primary outcome in a multivariable Cox regression model. Downstream referral rates to coronary angiography, revascularization, and cost of care spent on ischaemia testing did not significantly differ within the BMI categories.CONCLUSION: In this large multicentre registry, elevated BMI did not negatively impact the diagnostic quality and the effectiveness of risk stratification of patients referred for stress CMR.
KW - obesity
KW - prognosis
KW - stress cardiac MRI
KW - Predictive Value of Tests
KW - Prognosis
KW - Humans
KW - Gadolinium
KW - Magnetic Resonance Imaging, Cine
KW - Magnetic Resonance Imaging
KW - United States/epidemiology
KW - Contrast Media
KW - Obesity/diagnostic imaging
KW - Registries
KW - Perfusion Imaging
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UR - http://www.scopus.com/inward/citedby.url?scp=85105833246&partnerID=8YFLogxK
U2 - 10.1093/ehjci/jeaa281
DO - 10.1093/ehjci/jeaa281
M3 - Article
C2 - 33166994
AN - SCOPUS:85105833246
SN - 2047-2404
VL - 22
SP - 518
EP - 527
JO - European heart journal cardiovascular Imaging
JF - European heart journal cardiovascular Imaging
IS - 5
ER -