Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8 +T cells during primary influenza A viral infection

Jacqueline W. Mays, Nicole D. Powell, John T. Hunzeker, Mark L. Hanke, Michael T. Bailey, John F. Sheridan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner. However, the effect of SDR on the primary anti-viral immune response has not been elucidated. In this study, SDR-infected (INF) mice terminated viral gene expression earlier and mounted an enhanced pulmonary IAV-specific CD8 +T cell response versus controls. Additionally, SDR-INF mice had a more pro-inflammatory lung profile prior to and during infection and an attenuated corticosterone response. These data demonstrate neuroendocrine modification of the lung microenvironment and increased antigen-specific T cell activation, clonal expansion and viral control in stress-exposed mice.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalJournal of Neuroimmunology
Volume243
Issue number1-2
DOIs
StatePublished - Feb 29 2012

Keywords

  • HPA axis
  • Influenza
  • Stress
  • Sympathetic nervous system
  • T cell
  • Virus

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