sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

Márcio Bezerra-Santos; Lays G.Santos Bomfim; Camilla N.Oliveira Santos; Maria Wiliane N. Cunha; Eduardo J.Rocha de Moraes; Rodrigo A. Cazzaniga; Martha D.L. Tenório; Jonnia M.Sherlock Araujo; Lucas Menezes-Silva; Lucas Sousa Magalhães; Aline S. Barreto; Steven G. Reed; Malcolm S. Duthie; Michael W. Lipscomb; Roque Pacheco de Almeida; Tatiana Rodrigues de Moura; Amélia Ribeiro de Jesus

doi:10.3389/fmed.2023.1177375

sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

Márcio Bezerra-Santos
, Lays G.Santos Bomfim
, Camilla N.Oliveira Santos
, Maria Wiliane N. Cunha
, Eduardo J.Rocha de Moraes
, Rodrigo A. Cazzaniga
, Martha D.L. Tenório
, Jonnia M.Sherlock Araujo
, Lucas Menezes-Silva
, Lucas Sousa Magalhães
, Aline S. Barreto
, Steven G. Reed
, Malcolm S. Duthie
, Michael W. Lipscomb
, Roque Pacheco de Almeida
, Tatiana Rodrigues de Moura
, Amélia Ribeiro de Jesus

Pharmacology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

Original language	English (US)
Article number	1177375
Journal	Frontiers in Medicine
Volume	10
DOIs	https://doi.org/10.3389/fmed.2023.1177375
State	Published - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Bezerra-Santos, Bomfim, Santos, Cunha, de Moraes, Cazzaniga, Tenório, Araujo, Menezes-Silva, Magalhães, Barreto, Reed, Duthie, Lipscomb, de Almeida, de Moura and de Jesus.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

immune markers
inflammatory cytokine
leprosy
leprosy complications
soluble TREM-1

Publisher link

10.3389/fmed.2023.1177375

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Bezerra-Santos, M., Bomfim, L. G. S., Santos, C. N. O., Cunha, M. W. N., de Moraes, E. J. R., Cazzaniga, R. A., Tenório, M. D. L., Araujo, J. M. S., Menezes-Silva, L., Magalhães, L. S., Barreto, A. S., Reed, S. G., Duthie, M. S., Lipscomb, M. W., de Almeida, R. P., de Moura, T. R., & de Jesus, A. R. (2023). sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients. Frontiers in Medicine, 10, Article 1177375. https://doi.org/10.3389/fmed.2023.1177375

Bezerra-Santos, M, Bomfim, LGS, Santos, CNO, Cunha, MWN, de Moraes, EJR, Cazzaniga, RA, Tenório, MDL, Araujo, JMS, Menezes-Silva, L, Magalhães, LS, Barreto, AS, Reed, SG, Duthie, MS, Lipscomb, MW, de Almeida, RP, de Moura, TR & de Jesus, AR 2023, 'sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients', Frontiers in Medicine, vol. 10, 1177375. https://doi.org/10.3389/fmed.2023.1177375

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title = "sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients",

abstract = "Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.",

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author = "M{\'a}rcio Bezerra-Santos and Bomfim, \{Lays G.Santos\} and Santos, \{Camilla N.Oliveira\} and Cunha, \{Maria Wiliane N.\} and \{de Moraes\}, \{Eduardo J.Rocha\} and Cazzaniga, \{Rodrigo A.\} and Ten{\'o}rio, \{Martha D.L.\} and Araujo, \{Jonnia M.Sherlock\} and Lucas Menezes-Silva and Magalh{\~a}es, \{Lucas Sousa\} and Barreto, \{Aline S.\} and Reed, \{Steven G.\} and Duthie, \{Malcolm S.\} and Lipscomb, \{Michael W.\} and \{de Almeida\}, \{Roque Pacheco\} and \{de Moura\}, \{Tatiana Rodrigues\} and \{de Jesus\}, \{Am{\'e}lia Ribeiro\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Bezerra-Santos, Bomfim, Santos, Cunha, de Moraes, Cazzaniga, Ten{\'o}rio, Araujo, Menezes-Silva, Magalh{\~a}es, Barreto, Reed, Duthie, Lipscomb, de Almeida, de Moura and de Jesus.",

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AU - Bezerra-Santos, Márcio

AU - Bomfim, Lays G.Santos

AU - Santos, Camilla N.Oliveira

AU - Cunha, Maria Wiliane N.

AU - de Moraes, Eduardo J.Rocha

AU - Cazzaniga, Rodrigo A.

AU - Tenório, Martha D.L.

AU - Araujo, Jonnia M.Sherlock

AU - Menezes-Silva, Lucas

AU - Magalhães, Lucas Sousa

AU - Barreto, Aline S.

AU - Reed, Steven G.

AU - Duthie, Malcolm S.

AU - Lipscomb, Michael W.

AU - de Almeida, Roque Pacheco

AU - de Moura, Tatiana Rodrigues

AU - de Jesus, Amélia Ribeiro

N1 - Publisher Copyright: Copyright © 2023 Bezerra-Santos, Bomfim, Santos, Cunha, de Moraes, Cazzaniga, Tenório, Araujo, Menezes-Silva, Magalhães, Barreto, Reed, Duthie, Lipscomb, de Almeida, de Moura and de Jesus.

PY - 2023

Y1 - 2023

N2 - Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

AB - Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

KW - immune markers

KW - inflammatory cytokine

KW - leprosy

KW - leprosy complications

KW - soluble TREM-1

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U2 - 10.3389/fmed.2023.1177375

DO - 10.3389/fmed.2023.1177375

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AN - SCOPUS:85164933784

SN - 2296-858X

VL - 10

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 1177375

ER -

sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

Abstract

Bibliographical note

UN SDGs

Keywords

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