TY - JOUR
T1 - sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients
AU - Bezerra-Santos, Márcio
AU - Bomfim, Lays G.Santos
AU - Santos, Camilla N.Oliveira
AU - Cunha, Maria Wiliane N.
AU - de Moraes, Eduardo J.Rocha
AU - Cazzaniga, Rodrigo A.
AU - Tenório, Martha D.L.
AU - Araujo, Jonnia M.Sherlock
AU - Menezes-Silva, Lucas
AU - Magalhães, Lucas Sousa
AU - Barreto, Aline S.
AU - Reed, Steven G.
AU - Duthie, Malcolm S.
AU - Lipscomb, Michael W.
AU - de Almeida, Roque Pacheco
AU - de Moura, Tatiana Rodrigues
AU - de Jesus, Amélia Ribeiro
N1 - Publisher Copyright:
Copyright © 2023 Bezerra-Santos, Bomfim, Santos, Cunha, de Moraes, Cazzaniga, Tenório, Araujo, Menezes-Silva, Magalhães, Barreto, Reed, Duthie, Lipscomb, de Almeida, de Moura and de Jesus.
PY - 2023
Y1 - 2023
N2 - Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.
AB - Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.
KW - immune markers
KW - inflammatory cytokine
KW - leprosy
KW - leprosy complications
KW - soluble TREM-1
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U2 - 10.3389/fmed.2023.1177375
DO - 10.3389/fmed.2023.1177375
M3 - Article
C2 - 37457576
AN - SCOPUS:85164933784
SN - 2296-858X
VL - 10
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 1177375
ER -
