Strategies for studying complex genetic traits

Brandon M. Nathan, Joel N. Hirschhorn, Mark R. Palmert

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Common diseases and complex genetic traits such as adult height and the timing of puberty are modulated by multiple genes and environmental factors. Although methods such as resequencing of candidate genes, association studies, and linkage analysis have identified some of the genes that regulate common diseases and traits, most remain unknown. Novel experimental animal models such as chromosome substitution strains provide alternative means of identifying genes underlying these traits and diseases.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
Issue number6
StatePublished - Nov 1 2004


  • Genomics
  • Height
  • Puberty


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