Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition

Jukuan Zheng, Laura A. Smith Callahan, Jinkun Hao, Kai Guo, Chrys Wesdemiotis, R. A. Weiss, Matthew L. Becker

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.

Original languageEnglish (US)
Pages (from-to)1071-1073
Number of pages3
JournalACS Macro Letters
Issue number8
StatePublished - Aug 21 2012
Externally publishedYes


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