Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition

Jukuan Zheng; Laura A. Smith Callahan; Jinkun Hao; Kai Guo; Chrys Wesdemiotis; R. A. Weiss; Matthew L. Becker

doi:10.1021/mz3003775

Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition

Jukuan Zheng, Laura A. Smith Callahan, Jinkun Hao, Kai Guo, Chrys Wesdemiotis, R. A. Weiss, Matthew L. Becker

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.

Original language	English (US)
Pages (from-to)	1071-1073
Number of pages	3
Journal	ACS Macro Letters
Volume	1
Issue number	8
DOIs	https://doi.org/10.1021/mz3003775
State	Published - 2012

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title = "Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition",

abstract = "The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.",

author = "Jukuan Zheng and {Smith Callahan}, {Laura A.} and Jinkun Hao and Kai Guo and Chrys Wesdemiotis and Weiss, {R. A.} and Becker, {Matthew L.}",

year = "2012",

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AU - Zheng, Jukuan

AU - Smith Callahan, Laura A.

AU - Hao, Jinkun

AU - Guo, Kai

AU - Wesdemiotis, Chrys

AU - Weiss, R. A.

AU - Becker, Matthew L.

PY - 2012

Y1 - 2012

N2 - The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.

AB - The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.

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JO - ACS Macro Letters

JF - ACS Macro Letters

SN - 2161-1653

IS - 8

ER -

Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition

Abstract

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