Strain comparisons and developmental profile of the delta subunit of the murine GABAA Receptor

Wang Jia Bei, Paulo Kofuji, David R. Burt

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13 Scopus citations

Abstract

GABAA receptors are multisubunit inhibitory chloride channels in the brain which open in response to binding of -γ-aminobutyric acid (GABA) and are thought to be involved in some forms of seizures. We compare the sequence and expression of the GABAA receptor δ subunit in audiogenic seizure prone (DBA/2J) and seizure resistant (C57BL/6J) inbred strains of mice and also report this subunit's postnatal developmental profile. We did not detect any unique features in the 6 subunits of DBA/2J mice which might explain their seizure susceptibility, but did detect in some clones from both DBA/2J mice and C57BL/6J mice an unusual substitution of His for a conserved Tyr in the δ subunit's first putative transmembrane region.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalBrain Research Bulletin
Volume29
Issue number1
DOIs
StatePublished - Jul 1992

Keywords

  • Audiogenic seizures
  • DBA/2J and C57BL/6J mice
  • Epilepsy
  • GABA/benzodiazepine receptors
  • Polymorphism

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