Stool Based Testing for Colorectal Cancer: an Overview of Available Evidence

Kevin M. Rank, Aasma Shaukat

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Purpose of Review: The goal of this review is to summarize stool-based testing for colorectal cancer (CRC). The key questions answered in this review were the advantages and limitations of each available stool-based test for CRC and to examine their comparative efficacy. Recent Findings: Guaiac-based fecal occult blood testing (gFOBT) is no longer a relevant test for CRC screening. fecal immunochemical testing (FIT) tests, especially quantitative assays, are clearly a reliable stool-based test. Multitarget DNA (mtsDNA) stool testing may represent a viable option as well, although cost and test characteristics are yet fully defined. Summary: FIT and mtsDNA represent the options for stool-based CRC screening. In larger screening centers, quantitative FIT assays represent an attractive option for stool-based testing. Qualitative FIT has applicability in smaller centers. Although a large validation trial showed promising results for mtsDNA, further head-to-head trials with FIT will help define the ultimate role of mtsDNA. Ultimately, however, the best test for CRC screening is the one performed stool-based CRC screening as an initial or alternative option can increase participation in CRC screening.

Original languageEnglish (US)
Article number39
JournalCurrent gastroenterology reports
Issue number8
StatePublished - Aug 1 2017

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.


  • Advanced adenoma
  • Colorectal cancer
  • Fit
  • Screening
  • gFOBT
  • hsFOBT
  • mtsDNA


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