Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Arun Radhakrishnan, Xin Min Li, Rhoderick E Brown, Harden M. McConnell

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Some binary mixtures of cholesterol and phospholipids in monolayers have thermodynamic phase diagrams with two upper miscibility critical points. This feature has been interpreted in terms of 'condensed complexes' between the phospholipid and cholesterol. The present work gives evidence for the formation of complexes with a common simple integral stoichiometry in binary mixtures of cholesterol and a series of five sphingomyelins where the amide-linked acyl chain length is varied. This indicates that these complexes have a distinct geometry even though they form a liquid phase.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1511
Issue number1
DOIs
StatePublished - Mar 9 2001

Bibliographical note

Funding Information:
We are indebted to Thomas Anderson for helpful discussions concerning condensed complexes and the Penrose tiling of a plane. This work was supported by the NIH 5R01AI13587-25 (H.M.M.) and the NIGMS 45928 (R.E.B.).

Keywords

  • Critical point
  • Immiscibility
  • Liquid mixture
  • Membrane
  • Phase diagram

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