Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Arun Radhakrishnan; Xin Min Li; Rhoderick E Brown; Harden M. McConnell

doi:10.1016/S0005-2736(01)00274-7

Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Arun Radhakrishnan, Xin Min Li, Rhoderick E Brown, Harden M. McConnell

The Hormel Institute

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Some binary mixtures of cholesterol and phospholipids in monolayers have thermodynamic phase diagrams with two upper miscibility critical points. This feature has been interpreted in terms of 'condensed complexes' between the phospholipid and cholesterol. The present work gives evidence for the formation of complexes with a common simple integral stoichiometry in binary mixtures of cholesterol and a series of five sphingomyelins where the amide-linked acyl chain length is varied. This indicates that these complexes have a distinct geometry even though they form a liquid phase.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1511
Issue number	1
DOIs	https://doi.org/10.1016/S0005-2736(01)00274-7
State	Published - Mar 9 2001

Bibliographical note

Funding Information:
We are indebted to Thomas Anderson for helpful discussions concerning condensed complexes and the Penrose tiling of a plane. This work was supported by the NIH 5R01AI13587-25 (H.M.M.) and the NIGMS 45928 (R.E.B.).

Keywords

Critical point
Immiscibility
Liquid mixture
Membrane
Phase diagram

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10.1016/S0005-2736(01)00274-7

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AU - Brown, Rhoderick E

AU - McConnell, Harden M.

N1 - Funding Information: We are indebted to Thomas Anderson for helpful discussions concerning condensed complexes and the Penrose tiling of a plane. This work was supported by the NIH 5R01AI13587-25 (H.M.M.) and the NIGMS 45928 (R.E.B.).

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N2 - Some binary mixtures of cholesterol and phospholipids in monolayers have thermodynamic phase diagrams with two upper miscibility critical points. This feature has been interpreted in terms of 'condensed complexes' between the phospholipid and cholesterol. The present work gives evidence for the formation of complexes with a common simple integral stoichiometry in binary mixtures of cholesterol and a series of five sphingomyelins where the amide-linked acyl chain length is varied. This indicates that these complexes have a distinct geometry even though they form a liquid phase.

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KW - Critical point

KW - Immiscibility

KW - Liquid mixture

KW - Membrane

KW - Phase diagram

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Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers

Abstract

Bibliographical note

Keywords

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