Stimulatory Effect of Polynucleotides on Short Term Leukocyte Cultures

Harold M. Friedman, Arthur G. Johnson, Pauline Pan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Polyadenylic acid when complexed with polyuridylic acid, exerted an adjuvant effect in short-term human leukocyte cultures activated by purified protein derivative of tuberculin or in mixed leukocyte interactions. In contrast, stimulation of DNA synthesis in leukocytes by phytohemagglutinin was depressed by these homoribopolymers.

Original languageEnglish (US)
Pages (from-to)916-918
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Dec 1969

Bibliographical note

Funding Information:
Supported by USPHS research grant AI-1524 and Training Grant AI-00044-10.


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