Stimulatory Effect of Polynucleotides on Short Term Leukocyte Cultures

Harold M. Friedman; Arthur G. Johnson; Pauline Pan

doi:10.3181/00379727-132-34336

Stimulatory Effect of Polynucleotides on Short Term Leukocyte Cultures

Harold M. Friedman, Arthur G. Johnson, Pauline Pan

Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Polyadenylic acid when complexed with polyuridylic acid, exerted an adjuvant effect in short-term human leukocyte cultures activated by purified protein derivative of tuberculin or in mixed leukocyte interactions. In contrast, stimulation of DNA synthesis in leukocytes by phytohemagglutinin was depressed by these homoribopolymers.

Original language	English (US)
Pages (from-to)	916-918
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	132
Issue number	3
DOIs	https://doi.org/10.3181/00379727-132-34336
State	Published - Dec 1969

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Funding Information:
Supported by USPHS research grant AI-1524 and Training Grant AI-00044-10.

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title = "Stimulatory Effect of Polynucleotides on Short Term Leukocyte Cultures",

abstract = "Polyadenylic acid when complexed with polyuridylic acid, exerted an adjuvant effect in short-term human leukocyte cultures activated by purified protein derivative of tuberculin or in mixed leukocyte interactions. In contrast, stimulation of DNA synthesis in leukocytes by phytohemagglutinin was depressed by these homoribopolymers.",

author = "Friedman, {Harold M.} and Johnson, {Arthur G.} and Pauline Pan",

note = "Funding Information: Supported by USPHS research grant AI-1524 and Training Grant AI-00044-10. ",

year = "1969",

month = dec,

doi = "10.3181/00379727-132-34336",

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AU - Johnson, Arthur G.

AU - Pan, Pauline

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PY - 1969/12

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AB - Polyadenylic acid when complexed with polyuridylic acid, exerted an adjuvant effect in short-term human leukocyte cultures activated by purified protein derivative of tuberculin or in mixed leukocyte interactions. In contrast, stimulation of DNA synthesis in leukocytes by phytohemagglutinin was depressed by these homoribopolymers.

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Stimulatory Effect of Polynucleotides on Short Term Leukocyte Cultures

Abstract

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