Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes

H. M. Lederman; A. G. Johnson

Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes

H. M. Lederman
, A. G. Johnson

Administration (DMED)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The well-known adjuvant action of the homoribopolymer complex, polyadenylic-polyuridylic acid (poly A:U) was extended to an in vitro system utilizing human peripheral blood leucocytes (PBL) and tonsillar tissue. IgG synthesis by PBL plaque-forming cell and (PFC) formation by tonsillar tissue were enhanced by poly A:U. In addition, natural cytotoxicity by PBL against the human myeloid cell line K-562 was increased by this nontoxic adjuvant and was markedly stimulated by the removal of an adherent cell population.

Original language	English (US)
Pages (from-to)	643-653
Number of pages	11
Journal	RES Journal of the Reticuloendothelial Society
Volume	26
Issue number	SUPPL.
State	Published - 1979

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title = "Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes",

abstract = "The well-known adjuvant action of the homoribopolymer complex, polyadenylic-polyuridylic acid (poly A:U) was extended to an in vitro system utilizing human peripheral blood leucocytes (PBL) and tonsillar tissue. IgG synthesis by PBL plaque-forming cell and (PFC) formation by tonsillar tissue were enhanced by poly A:U. In addition, natural cytotoxicity by PBL against the human myeloid cell line K-562 was increased by this nontoxic adjuvant and was markedly stimulated by the removal of an adherent cell population.",

author = "Lederman, \{H. M.\} and Johnson, \{A. G.\}",

year = "1979",

language = "English (US)",

volume = "26",

pages = "643--653",

journal = "RES Journal of the Reticuloendothelial Society",

issn = "0033-6890",

publisher = "Reticuloendothelial Society",

number = "SUPPL.",

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T1 - Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes

AU - Lederman, H. M.

AU - Johnson, A. G.

PY - 1979

Y1 - 1979

N2 - The well-known adjuvant action of the homoribopolymer complex, polyadenylic-polyuridylic acid (poly A:U) was extended to an in vitro system utilizing human peripheral blood leucocytes (PBL) and tonsillar tissue. IgG synthesis by PBL plaque-forming cell and (PFC) formation by tonsillar tissue were enhanced by poly A:U. In addition, natural cytotoxicity by PBL against the human myeloid cell line K-562 was increased by this nontoxic adjuvant and was markedly stimulated by the removal of an adherent cell population.

AB - The well-known adjuvant action of the homoribopolymer complex, polyadenylic-polyuridylic acid (poly A:U) was extended to an in vitro system utilizing human peripheral blood leucocytes (PBL) and tonsillar tissue. IgG synthesis by PBL plaque-forming cell and (PFC) formation by tonsillar tissue were enhanced by poly A:U. In addition, natural cytotoxicity by PBL against the human myeloid cell line K-562 was increased by this nontoxic adjuvant and was markedly stimulated by the removal of an adherent cell population.

UR - https://www.scopus.com/pages/publications/0018641727

UR - https://www.scopus.com/pages/publications/0018641727#tab=citedBy

M3 - Article

C2 - 574900

AN - SCOPUS:0018641727

SN - 0033-6890

VL - 26

SP - 643

EP - 653

JO - RES Journal of the Reticuloendothelial Society

JF - RES Journal of the Reticuloendothelial Society

IS - SUPPL.

ER -

Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes

Abstract

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