Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes

H. M. Lederman, A. G. Johnson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The well-known adjuvant action of the homoribopolymer complex, polyadenylic-polyuridylic acid (poly A:U) was extended to an in vitro system utilizing human peripheral blood leucocytes (PBL) and tonsillar tissue. IgG synthesis by PBL plaque-forming cell and (PFC) formation by tonsillar tissue were enhanced by poly A:U. In addition, natural cytotoxicity by PBL against the human myeloid cell line K-562 was increased by this nontoxic adjuvant and was markedly stimulated by the removal of an adherent cell population.

Original languageEnglish (US)
Pages (from-to)643-653
Number of pages11
JournalRES Journal of the Reticuloendothelial Society
Volume26
Issue numberSUPPL.
StatePublished - Dec 1 1979

Fingerprint Dive into the research topics of 'Stimulation of human peripheral blood leukocytes by polyadenylic-polyuridic acid complexes'. Together they form a unique fingerprint.

  • Cite this