Stimulation of anti-tumor immunity by photodynamic therapy

Pawel Mroz, Javad T. Hashmi, Ying Ying Huang, Norbert Lange, Michael R. Hamblin

Research output: Contribution to journalReview article

102 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is a rapidly developing cancer treatment that utilizes the combination of nontoxic dyes and harmless visible light to destroy tumors by generating reactive oxygen species. PDT produces tumor-cell destruction in the context of acute inflammation that acts as a 'danger signal to the innate immune system. Activation of the innate immune system increases the priming of tumor-specific T lymphocytes that have the ability to recognize and destroy distant tumor cells and, in addition, lead to the development of an immune memory that can combat recurrence of the cancer at a later point in time. PDT may be also successfully combined with immunomodulating strategies that are capable of overcoming or bypassing the escape mechanisms employed by the progressing tumor to evade immune attack. This article will cover the role of the immune response in PDT anti-tumor effectiveness. It will highlight the milestones in the development of PDT-mediated anti-tumor immunity and emphasize the combination strategies that may improve this therapy.

Original languageEnglish (US)
Pages (from-to)75-91
Number of pages17
JournalExpert Review of Clinical Immunology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2011

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Photochemotherapy
Immunity
Neoplasms
Immune System
Reactive Oxygen Species
Coloring Agents
Inflammation
T-Lymphocytes
Light
Recurrence
Therapeutics

Keywords

  • Toll-like receptor agonists
  • anti-tumor immunity
  • cancer vaccines
  • cytotoxic T-lymphocytes
  • damage-associated molecular patterns
  • dendritic cells
  • photodynamic therapy
  • tumor-associated antigens

Cite this

Stimulation of anti-tumor immunity by photodynamic therapy. / Mroz, Pawel; Hashmi, Javad T.; Huang, Ying Ying; Lange, Norbert; Hamblin, Michael R.

In: Expert Review of Clinical Immunology, Vol. 7, No. 1, 01.01.2011, p. 75-91.

Research output: Contribution to journalReview article

Mroz, Pawel ; Hashmi, Javad T. ; Huang, Ying Ying ; Lange, Norbert ; Hamblin, Michael R. / Stimulation of anti-tumor immunity by photodynamic therapy. In: Expert Review of Clinical Immunology. 2011 ; Vol. 7, No. 1. pp. 75-91.
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