Stimulation by estradiol benzoate of hepatic β-hydroxy-β-methylglutaryl coenzyme A reductase in normal and ovariectomized rats

Y. J. Abul-Hajj

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5 Scopus citations

Abstract

The effect of estradiol benzoate on β-hydroxy-β-methylglutaryl coenzyme A reductase activity and plasma cholesterol level gas been studied in normal and ovariectomized rats. Daily administration of estradiol benzoate (25 μg and 100 μg) for 21 days resulted in a 1.7 and 2.5 fold increase in reductase activity in normal and ovariectomized rats, respectively. Plasma cholesterol levels were increased by 18% in normal rats and 38% in ovariectomized rats. The observed changes for the two treatment groups were similar even though the body weight for these groups were significantly different.

Original languageEnglish (US)
Pages (from-to)841-847
Number of pages7
JournalSteroids
Volume31
Issue number6
StatePublished - Dec 1 1978

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