Implantable devices for controlling medically intractable seizures nondestructively are rapidly advancing. These offer reversible, potentially, restorative options beyond traditional, surgical procedures, which rely, largely on resection or ablation of selected brain sites. Several lines of, investigation aimed at improving efficacy of these devices are discussed, ranging from identifying novel subcortical, white matter, or cell-type specific targets to engineering advances for adaptive techniques based- on continuous, dynamic system analysis.
|Original language||English (US)|
|Number of pages||5|
|Early online date||Apr 30 2021|
|State||Published - Oct 2021|
Bibliographical noteFunding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Timothy Denison: MRC MC_UU_0003/3; Esther Krook-Magnuson: The Winston and Maxine Wallin Neuroscience Discovery Fund Award, NIH/NINDS R01-NS112518 and NIH R01-NS104071, and the University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) initiative; David Mogul: NIH/NINDS R01 NS092760; Gregory Worrell: NIH Brain Initiative UH3-NS95495 and NIH/NINDS R01-NS09288203 (Worrell); Catherine Schevon: NIH/NINDS R01 NS084142 and R01 NS110669.
© The Author(s) 2021.
- electrical stimulation
- epileptic networks
- intractable epilepsy
- next-generation devices
- therapeutic devices