Stimulating Solutions for Intractable Epilepsy

Timothy Denison, Mohamad Koubeissi, Esther Krook-Magnuson, David Mogul, Gregory Worrell, Catherine Schevon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Implantable devices for controlling medically intractable seizures nondestructively are rapidly advancing. These offer reversible, potentially, restorative options beyond traditional, surgical procedures, which rely, largely on resection or ablation of selected brain sites. Several lines of, investigation aimed at improving efficacy of these devices are discussed, ranging from identifying novel subcortical, white matter, or cell-type specific targets to engineering advances for adaptive techniques based- on continuous, dynamic system analysis.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalEpilepsy Currents
Issue number5
Early online dateApr 30 2021
StatePublished - Oct 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Timothy Denison: MRC MC_UU_0003/3; Esther Krook-Magnuson: The Winston and Maxine Wallin Neuroscience Discovery Fund Award, NIH/NINDS R01-NS112518 and NIH R01-NS104071, and the University of Minnesota’s MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) initiative; David Mogul: NIH/NINDS R01 NS092760; Gregory Worrell: NIH Brain Initiative UH3-NS95495 and NIH/NINDS R01-NS09288203 (Worrell); Catherine Schevon: NIH/NINDS R01 NS084142 and R01 NS110669.

Publisher Copyright:
© The Author(s) 2021.


  • electrical stimulation
  • epileptic networks
  • intractable epilepsy
  • next-generation devices
  • therapeutic devices


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