"Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: A combined computational-experimental approach

Keyphrases

• Apolipoprotein A-I (ApoA-I) 100%
• High-density Lipoprotein Cholesterol (HDL-C) 100%
• Discoid 100%
• Molecular Dynamics 50%
• Molecular Mechanism 33%
• Hydrocarbons 33%
• Reconstitution 33%
• N-terminal Domain 33%
• High-density Lipoprotein Particles 33%
• Metabolism 16%
• Lipoproteins 16%
• Particle Size 16%
• Computational Strategies 16%
• Phospholipids 16%
• Thermal Fluctuations 16%
• Concentration Gradient 16%
• Helix 16%
• N-terminus 16%
• Dynamic Temperature 16%
• Deformable 16%
• Antiatherogenic 16%
• Biological Relevance 16%
• Reverse Cholesterol Transport 16%
• Simulated Annealing 16%
• Condensed Matter 16%
• Lipid Exchange 16%
• Polar Lipids 16%
• I-domain 16%
• Temperature Jump 16%
• Lipoprotein Structure 16%
• Lipid Particles 16%
• Lipoprotein Remodeling 16%
• Salt Bridge 16%
• N-terminal Loop 16%

Biochemistry, Genetics and Molecular Biology

• Lipoprotein(A) 100%
• High-Density Lipoprotein 100%
• Apolipoprotein 100%
• Dynamics 57%
• N-Terminus 57%
• Lipid 28%
• C-Terminus 28%
• Metabolic Pathway 14%
• Reverse Cholesterol Transport 14%
• Lipoprotein 14%
• Phospholipid 14%

Immunology and Microbiology

• High-Density Lipoprotein 100%
• Apolipoprotein 100%
• Dynamics 57%
• Amino Terminal Sequence 57%
• Carboxy Terminal Sequence 28%
• Cholesterol Transport 14%
• Atherosclerosis 14%
• Lipoprotein 14%