Steroid minimization for sirolimus-treated renal transplant recipients

Arthur J. Matas, Darla Granger, Dixon B. Kaufman, Minnie M. Sarwal, Ronald M. Ferguson, E. Steve Woodle, John S. Gill

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Steroids are associated with a myriad of post-transplant side effects. Therefore, as new immunosuppressive drugs have been developed, attempts have been made to minimize steroid exposure. Sirolimus (SRL) has been demonstrated to have efficacy in early and late post-transplant immunosuppression. Accordingly, numerous trials have studied steroid minimization (early and late post-transplant) in the context of SRL-containing protocols (either with or without a calcineurin inhibitor). We herein review these trials and show that recent studies have determined that both late steroid withdrawal and early rapid discontinuation can be successful with SRL immunosuppression.

Original languageEnglish (US)
Pages (from-to)457-467
Number of pages11
JournalClinical Transplantation
Volume25
Issue number3
DOIs
StatePublished - May 1 2011

Keywords

  • Immunosuppression
  • Kidney transplantation
  • Sirolimus
  • Steroid minimization

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