Stereotactic radiosurgery for skull base meningioma

Hiroshi Igaki, Keisuke Maruyama, Tomoyuki Koga, Naoya Murakami, Masao Tago, Atsuro Terahara, Masahiro Shin, Keiichi Nakagawa, Kuni Ohtomo

Research output: Contribution to journalArticle

25 Scopus citations


Stereotactic radiosurgery is now a treatment option for meningiomas, especially for high-risk patients such as those with skull base lesions. The clinical outcomes were retrospectively analyzed of stereotactic radiosurgery using the Leksell Gamma Knife® performed for 98 patients with 106 skull base meningiomas at the University of Tokyo Hospital between June 1990 and April 2006 and followed up for more than a year. After a median follow-up period of 53.2 months (range 12.2-204.4 months), local tumor control rates were 86.9% and 78.9% at 5 years and 10 years, respectively. Tumors with volume of 4 cm 3 or smaller (97.5% vs. 76.1% at 5 years, p = 0.001) and tumors completely included within the isodose line of 14 Gy or more (97.5% vs. 67.2% at 5 years, p = 0.0006) had higher local control rates. Postoperative residual tumors treated by stereotactic radiosurgery were controlled in all 25 cases. Cranial nerve deficits were improved, stable, and deteriorated in 12, 64, and 3 patients, respectively, after stereotactic radiosurgery. Stereotactic radiosurgery was effective treatment method for local control of skull base meningiomas, especially for small or postoperative residual tumors. Correct combination of microsurgery and radiosurgery leads to excellent local control.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalNeurologia Medico-Chirurgica
Issue number10
StatePublished - Dec 1 2009
Externally publishedYes


  • Gamma knife
  • Local control
  • Meningioma
  • Skull base
  • Stereotactic radiosurgery

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