Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates

Svjetlana Miocinovic, Jianyu Zhang, Weidong Xu, Gary S. Russo, Jerrold L. Vitek, Cameron C. McIntyre

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Methodologies for stereotactic neurosurgery and neurophysiological microelectrode recordings (MER) in non-human primate research typically rely on brain atlases that are not customized to the individual animal, and require paper records of MER data. To address these limitations, we developed a software tool (Cicerone) that enables simultaneous interactive 3D visualization of the neuroanatomy, neurophysiology, and neurostimulation data pertinent to deep brain stimulation (DBS) research studies in non-human primates. Cicerone allows for analysis of co-registered magnetic resonance images (MRI), computed tomography (CT) scans, 3D brain atlases, MER data, and DBS electrode(s) with predictions of the volume of tissue activated (VTA) as a function of the stimulation parameters. We used Cicerone to aid the implantation of DBS electrodes in two parkinsonian rhesus macaques, targeting the subthalamic nucleus in one monkey and the globus pallidus in the other. Cicerone correctly predicted the anatomical position of 79% and 73% of neurophysiologically defined MER sites in the two animals, respectively. In contrast, traditional 2D print atlases achieved 61% and 48% accuracy. Our experience suggests that Cicerone can improve anatomical targeting, enhance electrophysiological data visualization, and augment the design of stimulation experiments.

Original languageEnglish (US)
Pages (from-to)32-41
Number of pages10
JournalJournal of Neuroscience Methods
Volume162
Issue number1-2
DOIs
StatePublished - May 15 2007

Fingerprint

Deep Brain Stimulation
Microelectrodes
Primates
Atlases
Electrodes
Neuroanatomy
Subthalamic Nucleus
Neurophysiology
Globus Pallidus
Brain
Neurosurgery
Macaca mulatta
Research
Haplorhini
Magnetic Resonance Spectroscopy
Software
Tomography

Keywords

  • Deep brain stimulation
  • Microelectrode recording
  • Monkey
  • Software
  • Stereotactic neurosurgery
  • Surgical planning
  • Visualization

Cite this

Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates. / Miocinovic, Svjetlana; Zhang, Jianyu; Xu, Weidong; Russo, Gary S.; Vitek, Jerrold L.; McIntyre, Cameron C.

In: Journal of Neuroscience Methods, Vol. 162, No. 1-2, 15.05.2007, p. 32-41.

Research output: Contribution to journalArticle

Miocinovic, Svjetlana ; Zhang, Jianyu ; Xu, Weidong ; Russo, Gary S. ; Vitek, Jerrold L. ; McIntyre, Cameron C. / Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates. In: Journal of Neuroscience Methods. 2007 ; Vol. 162, No. 1-2. pp. 32-41.
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