Stereospecificity of hydrogen transfer from NADPH by steroid Δ4-5α- and Δ4-5β-reductase

Yusuf J. Abul-Hajj

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The saturation of the C-4,5 double bond of Δ4-3-ketosteroids catalyzed by Δ4-3-ketosteroid-5β-reductase has been shown to involve a hydride ion transfer from the A-position of NADPH to the 5β-position of the steroid while the reaction catalyzed by Δ4-3-ketosteroid-5α-reductase involves a hydride transfer from the B-position of NADPH to the 5α-position of the steroid. Thus, this study shows that Δ4-5β-reductase has A-stereospecificity while Δ4-5α-reductase has B-stereospecificity.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalSteroids
Volume20
Issue number3
DOIs
StatePublished - Sep 1972

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