Stereospecific binding of narcotics to brain cerebrosides

Horace H. Loh, Mook Cho Tae Mook Cho, Wu Ya-Chen Wu, E. Leong Way

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.

Original languageEnglish (US)
Pages (from-to)2231-2245
Number of pages15
JournalLife Sciences
Volume14
Issue number11
DOIs
StatePublished - Jun 1 1974

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