Stereospecific binding of narcotics to brain cerebrosides

Horace H. Loh, Mook Cho Tae Mook Cho, Wu Ya-Chen Wu, E. Leong Way

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Cerebrosides were shown to bind etorphine and naloxone stereo-specifically with high affinity. The relative potency of several narcotic analgesics in preventing the binding of etorphine and naloxone to cerebrosides correlated well with their reported intraventricular analgetic activity. The data indicate similarities between cerebroside sulfate and a purified opiate receptor from mouse brain which has been reported to be a proteolipid. Explanations for the apparent proteo-like behavior of the opiate receptor are provided.

Original languageEnglish (US)
Pages (from-to)2231-2245
Number of pages15
JournalLife Sciences
Issue number11
StatePublished - Jun 1 1974

Bibliographical note

Funding Information:
This investigation was supported by the U.S . Army Medical Research and Development Command under Contract No . DADA17-73-C-3006 .

Copyright 2014 Elsevier B.V., All rights reserved.


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