An enantioselective route for the synthesis of key fragment C1-C20 resident in microsclerodermins A and B is described. The route features deoxygenative rearrangement of an hydroxy-alkynoate and a highly enantio- and diastereo-controled iterative dihydroxylation as key reactions, starting from S-(-)-citronellol.
Bibliographical noteFunding Information:
S.S.S. thanks CSIR, New Delhi for financial support and S.C. thanks DST, New Delhi for a grant.
- Deoxygenative rearrangement
- Iterative Sharpless asymmetric dihydroxylation