Stereoselective synthesis of the C1-C20 segment of the microsclerodermins A and B

S. Chandrasekhar, S. Shameem Sultana

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

An enantioselective route for the synthesis of key fragment C1-C20 resident in microsclerodermins A and B is described. The route features deoxygenative rearrangement of an hydroxy-alkynoate and a highly enantio- and diastereo-controled iterative dihydroxylation as key reactions, starting from S-(-)-citronellol.

Original languageEnglish (US)
Pages (from-to)7255-7258
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number40
DOIs
StatePublished - Oct 2 2006

Bibliographical note

Funding Information:
S.S.S. thanks CSIR, New Delhi for financial support and S.C. thanks DST, New Delhi for a grant.

Keywords

  • Deoxygenative rearrangement
  • Iterative Sharpless asymmetric dihydroxylation
  • Stereoselective

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