Addition of dianions of 3-hydroxybutyrates to benzylideneaniline results in direct formation of trans S*-3-(l-hydroxyethyl)-1,4-diphenyl-2-azetidinone with 95% diastereoselectivity. Inversion of the configuration at Cα, gives the desired trans R*-2-azetidinone in high yield.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1984|