The effects of R(-)-, S(+) and R, S-1-2-5-dimethoxy-4-methylphenyl)-2-Aminopropane (DOM) were studied using rats responding under a fixed interval two-min schedule of food presentation. All three drugs decreased average rates of responding in a dose-related manner, with R-DOM being five to six times more potent than S-DOM but only about 1.2 times more potent than R,S-DOM. Relatively high doses of R,S-DOM and S-DOM increased the low response rates occurring at the beginning of the fixed interval and decreased the higher response rates occuring at the end of the interval (rate-dependent effects). These results are discussed in terms of the stereoselective metabolism of DOM and of the structural similarities between R-DOM and the behaviorally active isomer of LSD.
Bibliographical noteFunding Information:
Standard rat test cages (Grason-Stadler, West Concord, MA) 23 cm long, 29 cm wide and 19 cm high were installed in sound attenuating chambers (Grason-Stadler, West This work was supported by Public Health Service Grants MH-25487 and DA-02785. 2 Present address: Department of Pharmacology, University of Missouri, Medical Center, Columbia, MO 65201.
- DOM isomers
- Schedule-controlled behavior