Stereoselective effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on schedule-controlled behavior

R. Adron Harris, Diane Snell, Horace H. Loh

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effects of R(-)-, S(+) and R, S-1-2-5-dimethoxy-4-methylphenyl)-2-Aminopropane (DOM) were studied using rats responding under a fixed interval two-min schedule of food presentation. All three drugs decreased average rates of responding in a dose-related manner, with R-DOM being five to six times more potent than S-DOM but only about 1.2 times more potent than R,S-DOM. Relatively high doses of R,S-DOM and S-DOM increased the low response rates occurring at the beginning of the fixed interval and decreased the higher response rates occuring at the end of the interval (rate-dependent effects). These results are discussed in terms of the stereoselective metabolism of DOM and of the structural similarities between R-DOM and the behaviorally active isomer of LSD.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume7
Issue number4
DOIs
StatePublished - Oct 1977

Keywords

  • DOM isomers
  • Rate-dependence
  • Schedule-controlled behavior

Fingerprint Dive into the research topics of 'Stereoselective effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on schedule-controlled behavior'. Together they form a unique fingerprint.

  • Cite this