Stereochemical studies on medicinal agents I. Absolute configuration of certain analgesic (−)‐N‐[2‐(phenalkylmethylamino)propyl]propionanilides

Philip S Portoghese, Dennis L. Larson

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3 Citations (Scopus)

Abstract

The absolute configuration of certain (−)‐N‐[2‐(phenalkylmethylamino)propyl]‐propionanilides has been determined by relating them to D‐(−)‐alanine. The compounds corresponding to the L‐configuration have greater analgesic potency than those with the D‐configuration. An interpretation of the significance of the relationship of absolute configuration to analgesic activity is discussed in terms of an analgesic receptor surface.

Original languageEnglish (US)
Pages (from-to)302-305
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1964

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Analgesics
Alanine
3-chloro-4,4-dimethyl-2-oxazolidinone

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