Stem cells for skeletal muscle regeneration: Therapeutic potential and roadblocks

Fabrizio Rinaldi, Rita C R Perlingeiro

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Conditions involving muscle wasting, such as muscular dystrophies, cachexia, and sarcopenia, would benefit from approaches that promote skeletal muscle regeneration. Stem cells are particularly attractive because they are able to differentiate into specialized cell types while retaining the ability to self-renew and, thus, provide a long-term response. This review will discuss recent advancements on different types of stem cells that have been attributed to be endowed with muscle regenerative potential. We will discuss the nature of these cells and their advantages and disadvantages in regards to therapy for muscular dystrophies.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalTranslational Research
Volume163
Issue number4
DOIs
StatePublished - Apr 2014

Bibliographical note

Funding Information:
This project was supported by National Institutes of Health grants R01 AR055299 and RC1AR058118 as well as funding from the Muscular Dystrophy Association (#238127). All authors have read the journal's policy on disclosure of potential conflicts of interest. The authors declare no potential conflicts of interest.

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