Stem cells for skeletal muscle regeneration

Therapeutic potential and roadblocks

Fabrizio Rinaldi, Rita C R Perlingeiro

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Conditions involving muscle wasting, such as muscular dystrophies, cachexia, and sarcopenia, would benefit from approaches that promote skeletal muscle regeneration. Stem cells are particularly attractive because they are able to differentiate into specialized cell types while retaining the ability to self-renew and, thus, provide a long-term response. This review will discuss recent advancements on different types of stem cells that have been attributed to be endowed with muscle regenerative potential. We will discuss the nature of these cells and their advantages and disadvantages in regards to therapy for muscular dystrophies.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalTranslational Research
Volume163
Issue number4
DOIs
StatePublished - Jan 1 2014

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Muscular Dystrophies
Stem cells
Muscle
Regeneration
Skeletal Muscle
Stem Cells
Sarcopenia
Muscles
Cachexia
Therapeutics

Cite this

Stem cells for skeletal muscle regeneration : Therapeutic potential and roadblocks. / Rinaldi, Fabrizio; Perlingeiro, Rita C R.

In: Translational Research, Vol. 163, No. 4, 01.01.2014, p. 409-417.

Research output: Contribution to journalReview article

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